November 24, 2009
Why Circumcision Reduces HIV Risk
The decreased risk of HIV infection in circumcised men cannot be explained by a reduction in sores from conditions such as herpes, according to research published in PLoS Medicine.
In further analyses of data from 2 clinical trials including more than 5,000 men in rural Uganda, which had shown that circumcision reduced the risk of HIV infection in men by about 60%, Ron Gray of the Johns Hopkins Bloomberg School of Public Health and colleagues investigated factors associated with that reduction in risk. Specifically, they investigated whether infection with HSV-2, the virus that causes genital herpes, and whether genital ulcers of any cause, could account for the lower rates of HIV infection in the circumcised study participants.
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