February 5, 2010
Shape Of Barrett’s Epithelium Effects Prevalence Of Erosive Esophagitis
Barrett's epithelium is recognized as a complication of erosive esophagitis and is the pre-malignant condition for adenocarcinoma of the esophagus.
A research team from Yokohama City University School of Medicine hypothesized that some macroscopic features of Barrett's epithelium might be useful for identifying a subgroup with a high risk for the development of esophageal adenocarcinoma. Their study will be published on January 28, 2010 in the World Journal of Gastroenterology.They enrolled 869 patients who underwent endoscopy during a health checkup at their hospital. Based on the Prague C & M Criteria, they originally classified cases of Barrett's epithelium into two types based on its shape, namely, flame-like and lotus-like Barrett's epithelium, and into two groups based on its length, its C extent < 2 cm, and Ã¢“°¥ 2 cm.
They found that Barrett's epithelium was diagnosed in 374 cases (43%). Most of these were diagnosed as short-segment Barrett's epithelium. The prevalence of erosive esophagitis was significantly higher in subjects with flame-like than lotus-like Barrett's epithelium, and in those with a C extent of Ã¢“°¥ 2 cm than < 2 cm.
This study may represent a future strategy for intervention in the prevention of esophageal adenocarcinoma.
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