February 10, 2010
Useful Tool To Diagnose Primary Biliary Cirrhosis
Previous studies have shown that assessment of immunoglobulin subclasses in plasma cells by immunohistochemistry (IHC) may be useful in the histopathologic evaluation of autoimmune liver diseases. However, further studies are necessary in order to validate the diagnostic utility of IgM and IgG immunohistochemistry in this specific scenario.
A research team from United States evaluated the predominant plasma cell immunoglobulin subclass present in liver biopsies of patients with well-established autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), or primary sclerosing cholangitis (PSC) and assessed the diagnostic utility of IgM and IgG IHC in this setting. Their study will be published on January 28, 2010 in the World Journal of Gastroenterology.
Reference: Moreira RK, Revetta F, Koehler E, Washington MK. Diagnostic utility of IgG and IgM immunohistochemistry in autoimmune liver disease. World J Gastroenterol 2010; 16(4): 453-457
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