Helicobacter Pylori BabA2 Relates With Atrophic Gastritis In Costa Rica
The clinical outcome of gastric disease may involve differences in the prevalence or expression of bacterial virulence factors. Contrary to Asian studies, Western studies have disclosed associations between the presence of babA2 gene and gastric cancer. Evidence concerning BabA adhesin-associated genes is insufficient in Costa Rica, where the incidence of gastric cancer is very high, similar to Japan. The babA2 gene, which encodes BabA, may play a role in the development of gastric cancer in the Costa Rican population.
A research article to be published on January 28, 2010 in the World Journal of Gastroenterology addresses this question. Using data from 95 H. pylori-positive Costa Rican patients, and 95 H. pylori-positive Japanese patients, Dr. Sergio A Con and colleagues reported a higher prevalence of babA2 in Japan than in Costa Rica, while that of babA2/B was higher in Costa Rica than in Japan. In addition, in Costa Rican isolates only, babA2 was significantly associated with atrophic gastritis, which is considered to be a gastric premalignant lesion.
Reference: Con SA, Takeuchi H, Nishioka M, Morimoto N, Sugiura T, Yasuda N, Con-Wong R. Clinical relevance of Helicobacter pylori babA2 and babA2/B in Costa Rica and Japan. World J Gastroenterol 2010; 16(4): 474-478
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