March 3, 2010
How The Demons Of Dementia Possess And Damage Brain Cells
EPFL's Brain Mind Institute finds clues to the role of brain plaques typical in Alzheimer's patients
A study from EPFL's (Ecole Polytechnique F©d©rale de Lausanne) Laboratory of Neuroenergetics and Cellular Dynamics in Lausanne Switzerland, published today in the Journal of Neuroscience, may lead to new forms of treatment following a better understanding of how Amyloid-Beta found in cerebral plaques, typically present in the brain of Alzheimer's patients, may lead to neurodegeneration. Researchers in Lausanne have studied how the functions of certain cells called astrocytes"“which normally protect, repair, and transfer energy to neurons"“are impaired when "possessed" by aggregated Amyloid-Beta.
While the exact mechanisms by which the formation of plaques occurs and how they cause neurodegeneration and dementia is still a matter of debate in the scientific world, this study sheds a new light on how astrocytes may participate in the development of Alzheimer's disease. This new understanding of the interaction between Amyloid-Beta and astrocytes could lead to more effective therapies for Alzheimer's disease by trying to rescue astrocytic functions by deactivating the scavenger receptors.
The current study explores the causal relationship between the build-up of the Amyloid-Beta protein, associated with the formation of plaques, and the impairment of astrocyte's functions. Pierre Magistretti, director of the Brain Mind Institute and the Center for Psychiatric Neurosciences at CHUV/UNIL, and Igor Allaman, post doctoral fellow in Magistretti's lab, have succeeded in determining how built-up Amyloid-Beta infiltrates the astrocyte cells and alters their proper functioning, thus leading to the death of surrounding neurons. "To penetrate the astrocyte, the pathological protein goes through a 'scavenger' receptor." explains Igor Allaman. "Our study has shown that if we impair Amyloid-Beta build-up, or activation of this receptor, astrocytes continue to fulfill their normal neuroprotective functions even in the presence of the Amyloid-Beta."
The authors include Igor Allaman, from the Laboratory of Neuroenergetics and Cellular Dynamics in the Brain Mind Institute (EPFL), Mathilde Gavillet from the Laboratory of Neuroenergetics and Cellular Dynamics in the Brain Mind Institute (EPFL), Mireille B©langer from the Laboratory of Neuroenergetics and Cellular Dynamics in the Brain Mind Institute (EPFL), Thierry Laroche from the Cellular Imaging Facility in the Brain Mind Institute (EPFL), David Viertl from the Laboratory of Molecular Neurobiology and Functionnal Neuroproteomics in the Brain Mind Institute (EPFL), Hilal A. Lashuel from the Laboratory of Molecular Neurobiology and Functionnal Neuroproteomics in the Brain Mind Institute (EPFL), and Pierre J. Magistretti from the Laboratory of Neuroenergetics and Cellular Dynamics in the Brain Mind Institute (EPFL) and the Centre de Neurosciences Psychiatriques, Centre Hospitalier Universitaire Vaudois, DeÃ´partement de Psychiatrie, Site de Cery, CH-1008 Prilly/Lausanne, Switzerland.
Amyloid-Beta Aggregates Cause Alterations of Astrocytic Metabolic Phenotype: Impact on Neuronal Viability, Journal of Neuroscience, March 3, 2010, issue 9
Image Caption: Pictured are amyloid-beta proteins (in red) possessing the healthy astrocytes. Credit: EPFL - LNDC
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