March 29, 2010
Alzheimer’s Rat Created For Human Research
McGill University researcher and international collaborators genetically manipulate rat to create ideal model for studying Alzheimer's disease in humans
Prof. Claudio Cuello at McGill University and his collaborators have genetically manipulated rats that can emulate Alzheimer's disease in humans, enabling research that will include the development of new treatments. Alzheimer's is a devastating brain condition leading to a progressive decline of memory and other brain functions. Although research mice have been developed in the past, rats are more intelligent than other rodents and the behavior of these rats is rich and predictable, which means that for the first time researchers will be able to detect and study the evolution of learning and memory deficits.
The research was published on March 29, 2010 in the Volume 20:1, April 2010 edition of the Journal of Alzheimer's Disease. Prof. Cuello's work has been done with the financial support of the Canadian Institutes of Health Research and the Charles E Frosst/Merck Postdoctoral Fellowship Fund and with the collaboration with Leena Alhonen at Kuopio University in Finland and Fabio Canneva, Adriana Ducatenzeiler, Wanda Leon and Moshe Szyf of McGill's Department of Pharmacology and Therapeutics.
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