April 8, 2010
Expression Of Gelatinases In Gastric Cancer And Superficial Gastritis
Gastric cancer in Mexico is the most frequent gastrointestinal malignant neoplasm. Several precursor conditions, such as chronic gastritis, have been associated with the development of gastric cancer. The gelatinases MMP-2 and MMP-9, members of the metalloproteinase family, are fundamental enzymes in extracellular matrix remodeling. The extracellular matrix is composed of secreted molecules outside cells which provides structural support and regulates cell behavior.
The matrix metalloproteinase family is a group of 24 enzymes in humans that degrade components of extracellular matrix. The gelatinases comprise MMP-2 (gelatinase A) and MMP-9 (gelatinase B), both of which cleave several components of the extracellular matrix.
Reference: Sampieri CL, de la PeÃ±a S, Ochoa-Lara M, Zenteno-Cuevas R, Le³n-C³rdoba K. Expression of matrix metalloproteinases 2 and 9 in human gastric cancer and superficial gastritis. World J Gastroenterol 2010; 16(12): 1500-1505
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