April 19, 2010
New Insight Into Parkinson’s Disease
New research provides crucial insight into the pathogenic mechanisms of Parkinson's disease (PD), a prevalent neurodegenerative disorder. The study appears in the April 19 issue of the Journal of Cell Biology.
The identification of inherited mutations in genes such as Parkin and PINK1 ( PTEN-induced putative kinase 1 ) has revealed key factors in the development of familial forms of the disease. Parkin adds ubiquitin molecules to other proteins to trigger their degradation, while PINK1 regulates mitochondrial quality control. But how these two genes work together remains a mystery.
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