Quest PharmaTech Announces Dosing Of First Patient In Its Prostate Cancer Clinical Trial
TSX Venture: QPT
SL052 is an injectible, synthetic derivative of a small molecular weight compound called Hypocrellin, which is isolated from a parasitic fungus that grows on bamboo trees in
“SL052 photodynamic therapy is a promising treatment modality for prostate cancer because of its potential to minimize collateral damage compared to conventional treatment approaches,” said Dr.
The clinical trial is being conducted in two stages. In the first stage, up to six patients undergoing radical prostatectomy will be enrolled to study the prostate specific localization of SL052 after intra-arterial delivery. In the second stage, the safety and preliminary efficacy of SL052 PDT treatment with light dose escalation will be studied in 12 patients with localized prostate cancer. The treatment response will be monitored by MRI, prostate biopsy and changes in baseline PSA, which is an antigen associated with prostate disease progression.
This multi-disciplinary clinical trial is being conducted at the Princess Margaret and Sunnybrook Hospitals in
The American Cancer Society estimates there will be more than 192,000 new cases of prostate cancer in the U.S. in 2009, making it the third most prevalent form of cancer behind lung and breast cancer.
SL052 is a member of Quest PharmaTech’s SonoLight Portfolio with the potential to reduce or eliminate the side effects associated with currently available cancer treatment modalities: surgery, chemotherapy and radiotherapy. While Quest’s first clinical trial of the injectable form of SL052 will demonstrate its utility in photodynamic therapy, SL052 can also be adapted for use in sonodynamic as well as immunophotodynamic therapy for the treatment of prostate cancer. Its properties of activation with harmless physical agents (light and ultrasound), combined with its ability to generate cancer vaccines and stimulate an anti-cancer immune response provide an opportunity to develop SL052 in a broad-spectrum oncology arena targeting current unmet needs.
About Quest PharmaTech Inc.
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SOURCE Quest PharmaTech Inc.