Ardea Biosciences to Present Additional Data on Gout Program at the Annual European Congress of Rheumatology
SAN DIEGO, May 13 /PRNewswire-FirstCall/ — Ardea Biosciences, Inc. (Nasdaq: RDEA) today announced that it will present additional data from its completed Phase 2a and Phase 2b monotherapy studies of RDEA594, its lead product candidate for the treatment of hyperuricemia and gout, at the Annual European Congress of Rheumatology hosted by the European League Against Rheumatism (EULAR) in Rome, Italy on June 18th and 19th. The Company will also present additional RDEA594 and allopurinol combination data from its completed Phase 2a study, RDEA594 and febuxostat (UloricÃ‚®, Takeda Pharmaceutical Company Limited; AdenuricÃ‚®, Ipsen and Menarini) combination data from its completed Phase 1 study, as well as data on its next-generation URAT1 inhibitor program.
Presentation details are as follows:
Presentation Efficacy and Safety of a Range of Doses of RDEA594, a Novel Title: Uricosuric Agent, as a Single Agent in Hyperuricemic Gout Patients: Multicenter, Randomized, Double-Blind, Placebo- Controlled, Phase 2 Experience Session Oral Presentation Type: Session Abstract Session - What's New in the Crystal World Title: Date/Time: Friday, June 18, 2010 from 10:30 AM - 12:00 PM CEST Location: Room 10 B Presentation RDEA684, a Novel, Potent and Efficacious Inhibitor of Human Title: Urate Transporter, URAT1, with a Favorable Pharmacokinetic Profile, and No Mitochondrial Toxicity Session Oral Presentation Type: Session Abstract Session - What's New in the Crystal Word Title: Date/Time: Friday, June 18, 2010 from 10:30 AM - 12:00 PM CEST Location: Room 10 B Presentation Efficacy and Safety of RDEA594, a Novel Uricosuric Agent, as Title: Combination Therapy with Allopurinol in Gout Patients: Randomized, Double-Blind, Placebo-Controlled, Phase 2 Experience Session Poster Presentation Type: Date/Time: Saturday, June 19, 2010 from 10:15 AM - 12:00 PM CEST Location: Fiera Roma - Poster Areas in Halls 5 & 6 Presentation RDEA594, a Novel Uricosuric Agent, Shows Impressive Title: Reductions in Serum Urate Levels as Monotherapy and Substantial Additive Activity in Combination with Febuxostat in Normal Healthy Volunteers Session Type: Poster Presentation Date/Time: Saturday, June 19, 2010 from 10:15 AM - 12:00 PM CEST Location: Fiera Roma - Poster Areas in Halls 5 & 6
RDEA594, a selective URAT1 transporter inhibitor, is our lead product candidate for the treatment of hyperuricemia and gout currently in Phase 2 development. Over 500 people have safely received RDEA594, either by direct administration or through administration of RDEA806, its prodrug.
About Ardea Biosciences, Inc.
Ardea Biosciences, Inc., of San Diego, California, is a biotechnology company focused on the development of small-molecule therapeutics for the treatment of gout, cancer and human immunodeficiency virus (HIV). RDEA594, our lead product candidate for the treatment of hyperuricemia and gout, is a selective URAT1 transporter inhibitor in Phase 2 clinical development. Our next-generation URAT1 inhibitor program is currently in preclinical development. RDEA119, a potent and specific inhibitor of mitogen-activated ERK kinase (MEK) and our lead product candidate for the treatment of cancer, is being developed under a global license agreement with Bayer HealthCare AG. RDEA119 is currently being evaluated in advanced cancer patients with different tumor types as a single agent in a Phase 1 study as well as in combination with sorafenib (NexavarÃ‚®; Bayer HealthCare, Onyx Pharmaceuticals) in a Phase 1/2 study. Our two product candidates for the treatment of HIV, RDEA806 and RDEA427, are non-nucleoside reverse transcriptase inhibitors (NNRTIs), which have successfully completed a Phase 2a study in HIV patients and a human micro-dose pharmacokinetic study in healthy volunteers, respectively.
Statements contained in this press release regarding matters that are not historical facts are “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. Such statements include, but are not limited to, statements regarding our plans and goals, the expected properties and benefits of RDEA594, RDEA684, RDEA119, RDEA806, RDEA427 and our other compounds and the timing and results of our preclinical, clinical and other studies. Risks that contribute to the uncertain nature of the forward-looking statements include risks related to the outcome of preclinical and clinical studies, risks related to regulatory approvals, delays in commencement of preclinical and clinical studies, costs associated with our drug discovery and development programs, and risks related to the outcome of our business development activities. These and other risks and uncertainties are described more fully in our most recently filed SEC documents, including our Annual Report on Form 10-K and our Quarterly Reports on Form 10-Q, under the headings “Risk Factors.” All forward-looking statements contained in this press release speak only as of the date on which they were made. We undertake no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made.
SOURCE Ardea Biosciences, Inc.