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FDA Advisory Panel to Review Dental Amalgam

June 10, 2010

Agency to consider risks to vulnerable populations

SILVER SPRING, Md., June 10 /PRNewswire-USNewswire/ — The U.S. Food and Drug Administration today announced plans to hold an advisory panel on Dec. 14-15, 2010, to discuss several scientific issues that may affect the regulation of dental amalgam, used for direct filling of carious lesions or structural defects in teeth. The panel meeting will focus particularly on the potential risk to vulnerable populations, such as pregnant women, fetuses, and young children.

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Used to treat tooth decay, dental amalgam is a mixture of metals, composed of liquid mercury and a powdered amalgam alloy, composed primarily of silver, tin, and copper.

On July 28, 2009, the FDA issued a final rule that reclassified dental mercury from a class I device to class II, classified dental amalgam as a class II device, and designated special controls for dental amalgam, mercury and amalgam alloy. The special control for the devices is a guidance, titled “Class II Special Controls Guidance Document: Dental Amalgam, Mercury and Amalgam Alloy.”

Since that time, the agency has received several petitions raising various issues relating to the final rule and special controls.

The concerns raised include the adequacy of the risk assessment method used by the FDA in classifying dental amalgam, the bioaccumulative effect of mercury, the exposure of pediatric populations to mercury vapor, and the adequacy of the clinical studies on dental amalgam. In addition, a recent report on risk assessments issued by the National Academy of Sciences, titled “Science and Decisions: Advancing Risk Assessment, NAP 2009,” proposes new approaches to conducting risk assessments. These may be some of the issues the agency asks the advisory committee to review.

Details about the advisory panel meeting will be published in the Federal Register on June 11, 2010 and is available for advanced viewing today only.

For more information:

Advanced viewing: http://www.federalregister.gov/OFRUpload/OFRData/2010-14084_PI.pdf

FDA website on dental amalgam

http://www.fda.gov/MedicalDevices/ProductsandMedicalProcedures/DentalProducts/DentalAmalgam/default.htm

Petitions on dental amalgam

http://www.regulations.gov/search/Regs/home.html#documentDetail?R=09000064809fbe3f

http://www.regulations.gov/search/Regs/home.html#documentDetail?R=0900006480a1d1bc

http://www.regulations.gov/search/Regs/home.html#documentDetail?R=0900006480a80ae5

http://www.regulations.gov/search/Regs/home.html#documentDetail?R=0900006480a24048


    Media Inquiries: Dick Thompson, 301-796-7566, dick.thompson@fda.hhs.gov
    Consumer Inquiries: 888-INFO-FDA

SOURCE U.S. Food and Drug Administration


Source: newswire



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