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Many Lives Could Be Saved By Blood Clotting Drug

June 15, 2010

According to a paper published on Tuesday by The Lancet, an easy-to-use blood-clotting drug that costs just a few dollars can save up to 100,000 lives each year from road accidents and violence.

Doctors at the London School of Hygiene and Tropical Medicine tested an off-patent treatment called tranexamic acid (TXA) among 20,000 severely injured adults in 274 hospitals in 40 countries.

Participants received either one-gram of TXA by injection followed by another gram in a drip over the eight hours that followed.

The paper said the TXA reduced the risk of death from any cause by 10 percent compared with the placebo.

TXA scored a reduction of 15 percent over the placebo when it came to the risk of death by bleeding. 

The researchers said that every year, over a million people die as a result of traffic injuries, and another 1.6 million die as a result of acts of violence, and many could be saved by swift action to stop hemorrhaging.

“Each year about 600,000 injured patients bleed to death worldwide,” lead author Ian Roberts, a professor of epidemiology, told AFP news.

“Injuries may be accidental, for example, road crashes, or intentional, such as shootings, stabbings or land-mine injuries, and the majority of deaths occur soon after injury.”

TXA works by reducing the breakdown of clots.  The drug, which costs about $4.50 per gram, is manufactured by a number of companies.

The paper said that if TXA became widely available and was used promptly, it could save as many as 100,000 lives a year, 13,000 of them in India and 12,000 in China, where road deaths are surging.

“The drug is inexpensive and could be given in hospitals worldwide,” Etienne Krug, director of violence and injury prevention and disability at the UN’s World Health Organization (WHO), told AFP.

“It is essential that doctors are aware of these results and take them into account in the emergency management of seriously injured patients.”

The trial was carried out to determine whether TXA was effective and whether it had bad side effects, like increasing the risk of heart attacks, strokes and lung clots.

The authors said on the latter score, there was no increase in any of these complications.

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