August 4, 2010
New Estimates Of The Global Population At Risk Of Plasmodium Vivax Malaria
A new evidence-based global distribution map of Plasmodium vivax malaria, published August 3 in the open-access journal PLoS Neglected Tropical Diseases, is used to estimate that 2.85 billion people lived at risk of infection with this parasite in 2009. The map, created as part of the Malaria Atlas Project (MAP), a multinational research collaboration funded mainly by the Wellcome Trust, reviews a host of information that challenges the dogma that P. vivax transmission is absent through large swathes of Africa and uses novel methods - including new global maps of the protective Duffy negativity blood condition - to estimate global populations at risk.
The study concludes that of the almost 3 billion people exposed to some risk of P. vivax transmission in 2009, 91% of them live in Central and South East Asia. Importantly, more than half of those exposed to this risk live in areas where P. vivax malaria transmission is extremely low or unstable and where prospects of sustained control and elimination are relatively good.
"This study represents the first step in our efforts to provide the malaria control and research community with an evidence-based cartography of P. vivax malaria," says co-author Dr. Simon Hay of the University of Oxford. "We can now focus on trying to model the endemicity of the disease to provide more detailed global burden estimates, although this is complicated by the unusual biology of P. vivax".
Co-author Dr Carlos Guerra adds: "New evidence shows that P. vivax malaria is not as benign as was thought, and yet, as our study shows, remains the most widespread form of human malaria. Understanding where transmission of this parasite occurs at the global scale is fundamental in planning strategies for the control of this debilitating, and often lethal, disease".
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