September 7, 2010

Treating Fractures That Don’t Heal

(Ivanhoe Newswire) "“ Many bone fractures don't heal completely or properly, but this new model shows why fractures aren't healing properly and how they can be treated to restart the healing process and produce a strong healthy bone.

About 5 to 10 percent of bone fractures the healing process doesn't succeed in fully repairing the bone, which leads to non-unions- failure of a fracture to unite and heal. Using an animal model mimicking a clinical non-union situation and a mathematical model developed for studying normal fracture healing.

The researchers developed ways to treat non-unions by transplanting cells from the bone marrow to the fracture. This was tested in a pilot animal experiment, and in both simulations and experiments showed bony union formation between the fractured bone ends.

This experiment showed the potential for using cell transplantation for the treatment for non-union fractures and the possibility for healing aging people with fractures that won't heal.

SOURCE: PLoS, published online September 1, 2010