Tocotrienols Shown to be Effective in Lowering Fat Levels in Blood

October 17, 2010

SINGAPORE, Oct. 17 /PRNewswire-Asia/ — Scientists from Singapore found
that tocotrienols, which are members of the Vitamin E family, are effective in
lowering the levels of triglyceride, a form of fat in the blood. High levels
of triglyceride are closely linked to an increased risk of cardiovascular and
metabolic diseases.

The scientists found that gamma and delta tocotrienols, derived naturally
from palm oil, are potent in lowering triglyceride levels by 28% in the blood
of human subjects after two months of supplementation. In addition,
tocotrienol-treated subjects in the double blind, placebo-controlled human
trial showed decreasing trends in average weight, body fat mass, body fat
percentage and waist measurement. The study hence points to the potential of
tocotrienols as a natural remedy in fighting obesity.

This research study, which involves collaboration between scientists at
Davos Life Science (Singapore), researchers at Malaysia Palm Oil Board
(Malaysia) and Phytopharma Co. Ltd. (Japan), was reported in the October 2010
issue of Journal of Atherosclerosis and Thrombosis, the reputable publication
of the Japan Atherosclerosis Society. The study involved twenty human subjects
with borderline hypercholesterolemia and was conducted in Takara Clinic in
Japan. The subjects were not receiving any cholesterol-lowering medications at

“Other studies have shown triglyceride-lowering effects of
eicosapentaenoic acid (EPA), a polyunsaturated fatty acid found in oily fish,
which is approved by Japan’s Ministry of Health as a treatment for
hyperlipidemia. This study reveals that tocotrienols have a more significant
serum triglyceride-lowering effect than EPA. More importantly, tocotrienol did
not have any observable side effects, suggesting that it could become a
natural remedy to lower triglycerides effectively,” said Dr. Daniel Yap, Head
for Tocotrienol R&D, Davos Life Science.

An elevated triglyceride level is one of the risk factors for the
identification of metabolic syndrome, which is linked to an increase risk of
cardiovascular disease, diabetes and stroke. This study demonstrates — for
the first time — that gamma and delta tocotrienols work to lower triglyceride
levels, by directly suppressing genes that enable triglyceride production
(SREBP1/2, DGAT2 and APOB100), suggesting that tocotrienols are able to
directly regulate triglyceride synthesis in the body. At the same time, this
down-regulation also translates into a reduction in the level of triglyceride
transport lipoproteins (VLDL and chylomicron), which distribute fats around
the body. The study supports its in vitro research findings, by demonstrating
the triglyceride-lowering effect of tocotrienols in both mice models and human
clinical studies.

Moreover, the study also showed that tocotrienols may inhibit the
development of atherosclerosis, a medical condition in which fatty plaque,
resulting from oxidation of LDL-cholesterol (also known as “bad” cholesterol),
builds up inside the arteries. It was found that gamma tocotrienol can enhance
the removal of LDL-cholesterol from the blood, by inducing the expression of
LDL receptors. This is a key step in achieving healthy blood lipid levels.

“Our studies show that tocotrienols have the potential for the prevention
or treatment of metabolic syndrome. This research contributes further evidence
that natural tocotrienols is a far more powerful form of vitamin E with unique
health-related benefits not shared by alpha-tocopherol, the common form of
vitamin E,” said Mr Arthur Ling, CEO of Davos Life Science Singapore, a
company specialising in the research & development and production of

About Davos Life Science

Davos Life Science Pte Ltd was set up in 2004 as a manufacturer that
isolates and purifies natural tocotrienols for use in supplements, functional
food, personal care, and pharmaceutical formulations. Davos Life Science
markets its tocotrienols under the name “Natural e3″, which has GRAS status, a
food safety standard administered in accordance with the regulations of the
U.S. FDA. The company has established the world’s largest R&D centre dedicated
to tocotrienols and the world’s largest manufacturing facility for the
production of natural tocotrienols. For more information, visit

SOURCE Davos Life Science Pte Ltd

Source: newswire

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