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Last updated on April 16, 2014 at 7:25 EDT

Leading European Center Begins Treatments Using Brachytherapy Devices and Software from Varian Medical Systems

November 8, 2010

PARIS, Nov. 8, 2010 /PRNewswire/ — One of Europe’s leading hospitals offering brachytherapy treatments for cancer patients has commenced treatments using three advanced computer-controlled afterloader devices and a full suite of planning software from Varian Medical Systems (NYSE: VAR). French cancer patients will benefit from advanced brachytherapy treatments following the decision by Institute Gustave-Roussy (IGR) in Paris to install Varian’s GammaMed(TM) PDR (pulsed dose rate) afterloaders to replace five aging low dose rate brachytherapy devices.

Dr. Christine Haie-Meder, head of brachytherapy at IGR, said three gynecological cancer patients had been treated on the new equipment so far. “These new devices and software enable us to increase our optimized 3D-based brachytherapy procedures, especially in gynecological tumors, as well as enabling us to replace low dose rate with pulsed dose rate treatments,” said Dr. Haie-Meder. “For patients, this means we can potentially increase the quality of the treatments.”

Brachytherapy involves treating cancer by temporarily placing radioactive sources within or adjacent to the tumor. Pulsed dose rate brachytherapy involves short pulses of radiation, typically once an hour, twenty-four hours per day, to simulate the overall rate and effectiveness of low dose rate treatments. Typical tumor sites treated by PDR brachytherapy are gynecological, head and neck, anal canal and penile cancers, as well as pediatric tumors such as rhabdomyosarcoma.

One of the key factors in IGR’s decision to acquire GammaMed afterloaders was the efficacy of Varian’s brachytherapy software, including BrachyVision(TM) treatment planning software. “The software appears to be very easy-to-use and reliable and is ideal for MRI-based brachytherapy imaging,” said Dr Haie-Meder. “We have a very modern approach to brachytherapy treatments with regular use of CT or MRI 3D-based dosimetry and optimization, and the Varian software will aid us in this approach.”

“We are honored that clinicians at IGR, one of the world’s leading brachytherapy centers, have confidence that Varian devices and software enable them to meet their high treatment standards,” said Hosea Mitchell, VP of Varian BrachyTherapy.

IGR is one of Europe’s leading exponents of brachytherapy, with a long history of treating patients using this technique. Over 450 patients are treated using brachytherapy at IGR each year, with a focus on gynecological, prostate, penile, head/neck, pediatric, breast, anal canal and bronchial cancers.

Brachytherapy is an extremely well established treatment technique which plays an essential role as a standard of care for advanced stage cervix cancer patients. This is a field in which Dr. Haie-Meder has particular expertise and has led many key developments in the technique as indicated by some of following publications:


    Physics Contributions and Clinical Outcome With 3D-MRI-Based Pulsed-
     Dose-Rate Intracavitary Brachytherapy in Cervical Cancer Patients
    International Journal of Radiation Oncology*Biology*Physics, Volume
     74, Issue 1, 1 May 2009, Pages 133-139
    Cyrus Chargari, Nicolas Magne, Isabelle Dumas, Taha Messai, Lisa
     Vicenzi, Norman Gillion, Philippe Morice, Christine Haie-Meder

    Inter-observer comparison of target delineation for MRI-assisted
     cervical cancer brachytherapy: Application of the GYN GEC-ESTRO
     recommendations
    Radiotherapy and Oncology, Volume 91, Issue 2, May 2009, Pages
     166-172
    Johannes C.A. Dimopoulos, Veronique De Vos, Daniel Berger, Primoz
     Petric, Isabelle Dumas, Christian Kirisits, Carey B. Shenfield,
     Christine Haie-Meder, Richard Potter
    Preliminary results of a prospective multicentric French study of PDR
     3D brachytherapy for cervix carcinoma
    Brachytherapy, Volume 7, Issue 2, April-June 2008, Page 96
    Christine Brunaud, Christine Haie-Meder, Didier Peiffert, STIC PDR
     Group

    Intercomparison of treatment concepts for MR image assisted
     brachytherapy of cervical carcinoma based on GYN GEC-ESTRO
     recommendations
    Radiotherapy and Oncology, Volume 78, Issue 2, February 2006, Pages
     185-193
    Stefan Lang, An Nulens, Edith Briot, Christian Kirisits, Marisol De
     Brabandere, Isabelle Dumas, Johannes Dimopoulos, Peter Petrow,
     Dietmar Georg, Erik Van Limbergen, Christine Haie-Meder, Richard
     Potter

    Recommendations from gynaecological (GYN) GEC ESTRO working group
     (II): Concepts and terms in 3D image-based treatment planning in
     cervix cancer brachytherapy-3D dose volume parameters and aspects of
     3D image-based anatomy, radiation physics, radiobiology
    Radiotherapy and Oncology, Volume 78, Issue 1, January 2006, Pages
     67-77
    Richard Potter, Christine Haie-Meder, Erik Van Limbergen, Isabelle
     Barillot, Marisol De Brabandere, Johannes Dimopoulos, Isabelle
     Dumas, Beth Erickson, Stefan Lang, An Nulens, Peter Petrow, Jason
     Rownd, Christian Kirisits

    3D image based concepts in brachytherapy for cervix cancer
    European Journal of Cancer Supplements, Volume 3, Issue 3, October
     2005, Page 416
    Christine Haie-Meder and On behalf of the GYNE GEC ESTRO working
     group
    Recommendations from Gynaecological (GYN) GEC-ESTRO Working Group
     (I): concepts and terms in 3D image based 3D treatment planning in
     cervix cancer brachytherapy with emphasis on MRI assessment of GTV
     and CTV
    Radiotherapy and Oncology, Volume 74, Issue 3, March 2005, Pages
     235-245
    Christine Haie-Meder, Richard Potter, Erik Van Limbergen, Edith
     Briot, Marisol De Brabandere, Johannes Dimopoulos, Isabelle Dumas,
     Taran Paulsen Hellebust, Christian K! irisits, Stefan Lang, Sabine
     Muschitz, Juliana Nevinson, An Nulens, Peter Petrow, Natascha
     Wachter-Gerstner
    7Dose-volume histogram analysis for tumor and critical organs in
     intracavitary brachytherapy of cervical cancer with the use of MRI
    Radiotherapy and Oncology, Volume 60, Supplement 1, 2001, Page S3
    E. Briot, R. de Crevoisier, P. Petrow, M. Delapierre, M. Albano, C.
     Petit, H. Kafrouni, C. Haie-Meder

Editorial contact: Neil Madle, Varian Medical Systems, +44 7786 526068, neil.madle@varian.com

ABOUT VARIAN MEDICAL SYSTEMS

Varian Medical Systems, Inc., of Palo Alto, California, is the world’s leading manufacturer of medical devices and software for treating cancer and other medical conditions with radiotherapy, radiosurgery, proton therapy, and brachytherapy. The company supplies informatics software for managing comprehensive cancer clinics, radiotherapy centers and medical oncology practices. Varian is a premier supplier of tubes and digital detectors for X-ray imaging in medical, scientific, and industrial applications and also supplies X-ray imaging products for cargo screening and industrial inspection. Varian Medical Systems employs approximately 5,100 people who are located at manufacturing sites in North America, China, and Europe and in its 79 sales and support offices around the world. For more information, visit http://www.varian.com/

SOURCE Varian Medical Systems, Inc.


Source: newswire