November 10, 2010
Trojan Horse Ploy To Sneak Protective Drug Into Brains Of Stroke Patients
Scientists are reporting development of a long-sought method with the potential for getting medication through a biological barrier that surrounds the brain, where it may limit the brain damage caused by stroke. Their approach for sneaking the nerve-protective drug erythropoietin into the brain is medicine's version of the Trojan Horse ploy straight out of ancient Greek legend. It also could help people with traumatic head injuries, Parkinson's disease, and other chronic brain disorders. Their report appears in ACS' Molecular Pharmaceutics, a bi-monthly journal.
William Pardridge and colleagues explain that erythropoietin is a protective protein that has engendered great medical interest for its potential in protecting brain cells cut off from their normal blood supply by a stroke, or brain attack. Tests, however, show that erythropoietin, like other drugs, cannot penetrate a tightly-knit layer of cells called the blood-brain-barrier that surrounds and protects the brain from disease-causing microbes and other harmful material. Other proteins, however, can penetrate the barrier, and the scientists decided to test one of them as a Trojan Horse to sneak in erythropoietin.
On the Net: