December 14, 2010
High Levels Of ‘Good’ Cholesterol May Be Associated With Lower Risk Of Alzheimer’s Disease
High levels of high-density lipoprotein (HDL), also known as "good" cholesterol, appear to be associated with a reduced risk for Alzheimer's disease in older adults, according to a report in the December issue of Archives of Neurology, one of the JAMA/Archives journals.
"Dyslipidemia [high total cholesterol and triglycerides] and late-onset Alzheimer's disease are highly frequent in western societies," the authors write as background information in the article. "More than 50 percent of the U.S. adult population has high cholesterol. About 1 percent of people age 65 to 69 years develop Alzheimer's disease, and the prevalence increases to more than 60 percent for people older than 95 years."
To determine this association, data were collected from medical, neurological and neuropsychological evaluations. Additionally, the authors assigned a diagnosis of "probable" Alzheimer's disease when onset of dementia could not be explained by any other disorder. A diagnosis of "possible" Alzheimer's disease was made when the most likely cause of dementia was Alzheimer's disease but there were other disorders that could contribute to the dementia, such as stroke or Parkinson disease.
During the course of follow-up, there were 101 new cases of Alzheimer's disease, of which 89 were probable and 12 were possible. The mean (average) age of individuals at the onset of probable and possible Alzheimer's disease was 83 years, and compared with people who were not diagnosed with incident Alzheimer's disease, those who did develop dementia were more often Hispanic and had a higher prevalence of diabetes at the start of the study. Higher plasma levels of HDL cholesterol were associated with a decreased risk of both probable and possible Alzheimer's disease, even after adjusting for vascular risk factors and lipid-lowering treatments. Although higher plasma total cholesterol, non-HDL cholesterol and LDL cholesterol levels also were associated with decreased risks of probable and possible Alzheimer's disease, these associations became non-significant after adjusting for vascular risk factors and lipid-lowering treatments.
"In this study, higher levels of HDL cholesterol were associated with a decreased risk of both probable and possible Alzheimer's disease," the authors conclude. "An important consideration in the interpretation of the results is that it was conducted in an urban multiethnic elderly community with a high prevalence of risk factors for mortality and dementia. Thus, our results may not be generalizeable to cohorts with younger individuals or to cohorts with participants with a lower morbidity [disease] burden."
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