January 14, 2011
Transplant Treats Disease in the Eye
(Ivanhoe Newswire) -- A new eye transplant releases the medication dexamethasone within the eye to safely and effectively treat some types of uveitis, swelling and inflammation in the eye's middle layer, according to new research.
"Uveitis refers to a group of intraocular inflammatory diseases that cause 10 percent to 15 percent of blindness in the developed world," the authors were quoted as saying. "Despite advances in immunosuppressive treatments, corticosteroids remain the mainstay of therapy."
They found that after eight weeks, 47 percent of the 0.7-mg patients reported 0 vitreous haze, or hazy vision due to inflammation. Additionally, 36 percent of those who received the 0.35-mg implant reported 0 vitreous haze compared to 12 percent of the sham procedure patients.
In addition, the percentage of eyes that achieved at least a 15-letter improvement in visual acuity was two- to six-fold greater in both implant groups than in the control group throughout the study.
"Typically, the most common adverse events associated with intravitreal corticosteroids, which may have impacted use in the past, included increases in intraocular pressure [pressure within the eye] and cataract. On any given follow-up visit in the present study, substantial increases in intraocular pressure (to 25 millimeters of mercury or greater) occurred in less than 10 percent of treated eyes," the authors write. In addition, only one of 62 phakic (with lenses) eyes required surgery to remove a cataract.
"In conclusion, the present study demonstrated that in patients with non-infectious intermediate or posterior uveitis, a single dose of the dexamethasone intravitreal implant was well-tolerated and produced significant improvements in intraocular inflammation and visual acuity that persisted for six months," the authors conclude. "Overall, the 0.7-milligram dexamethasone intravitreal implant demonstrated greater efficacy than the 0.35-milligram dexamethasone intravitreal implant, with similar safety."
SOURCE: Archives of Ophthalmology, published online January 10, 2011