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Last updated on April 17, 2014 at 21:23 EDT

Mysterious Syndrome Causes Semen Allergy

January 17, 2011

Men suffering from flu-like symptoms such as feverishness, runny nose, extreme fatigue and burning eyes immediately after ejaculation could be suffering from an allergic reaction to their own semen.

Documented in medical journals since 2002, men with the condition, known as post orgasmic illness syndrome or POIS, get flu-like symptoms immediately after they ejaculate. Symptoms can last for up to week.

Marcel Waldinger, a professor of sexual psychopharmacology at Utrecht University in the Netherlands, published two studies which suggest that men with POIS have an allergy to their own semen, and that a treatment known as hypersensitization therapy can help reduce its impact.

POIS is largely unknown among family doctors and experts say many men who suffer the condition feel ashamed about it and confused about what is wrong. Waldinger said while the syndrome is probably rare, it is likely that many men who suffer with it do not know it is a recognized condition.

Waldinger and colleagues analyzed 45 Dutch men who were diagnosed with the illness. “They didn’t feel ill when they masturbated without ejaculating, but as soon as the semen came from the testes, after that they became ill, sometimes within just a few minutes,” Waldinger said.

Thirty-three of them agreed to undergo a standard skin-prick allergy test using a diluted form of their own semen. Twenty-nine of those 45 men, or 88 percent, had a positive skin reaction indicating an auto-immune response, or allergic reaction.

“These results are a very important breakthrough in the research of this syndrome,” Waldinger said in a telephone interview with Reuters.

He said the findings “contradict the idea that the complaints have a psychological cause” and show that an auto-allergic reaction to semen is the most likely cause.

In a second study in the same journal, Waldinger’s team decided to treat two of the volunteers with allergen immunotherapy, which repeatedly exposes the body to small but gradually increasing amounts of the allergen over several years. In the POIS therapy, the men were given skin injections containing their own semen in gradually less diluted forms.

The study’s results showed that after one and three years respectively, the men showed a significantly reduction in their POIS symptoms. “It’s a very slow process. It is used for all sorts of allergies and can sometimes take up to 5 years,” Waldinger said. In the light of the first results, his team have now started several more POIS patients on hypersensitization therapy.

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