January 20, 2011
A Novel Function Of Anti-Diuretic Hormone Vasopressin In The Brain
Preventing the vasopressin neurons from swelling, and maintaining their size
The anti-diuretic hormone "vasopressin" is released from the brain, and known to work in the kidney, suppressing the diuresis. Here, the Japanese research team led by Professor Yasunobu OKADA, Director-General of National Institute for Physiological Sciences (NIPS), and Ms. Kaori SATO, a graduate student of The Graduate University for Advanced Studies, clarified the novel function of "vasopressin" that works in the brain, as well as in the kidney via the same type of the vasopressin receptor, to maintain the size of the vasopressin neurons. It might be a useful result for clarification of the condition of cerebral edema which swells along with the brain trauma or the cerebral infarction, and for its treatment method development. This result of the study is reported in the Science Signaling magazine (issue on January 25, 2011) which is the offshoot of Science magazine published by American Association for the Advancement of Science (AAAS).
This study became possible by labeling vasopressin neurons of the rat brain hypothalamus with green fluorescent protein (GFP)Ã¯¼Å½(The transgenic rat was developed by Professor Yoichi UETA; University of Occupational and Environmental Health, Japan)
Professor OKADA says that "It is a surprising result that the same type of the vasopressin receptor as the kidney exists in the brain and the vasopressin works on it. It can be expected to clarify the condition of cerebral edema which swells along with the brain trauma or the cerebral infarction, and to develop its treatment method.
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