March 22, 2011
Specific Genetic Mutations Associated With Preeclampsia
Specific genetic mutations in women with autoimmune diseases are associated with preeclampsia"”a common pregnancy-related problem that can threaten the health of both baby and mother. Furthermore, investigation of these specific genetic mutations has revealed an association between similar mutations and preeclampsia in women without any underlying autoimmune disease. These are the findings of a study by Jane Salmon a rheumatologist from Hospital for Special Surgery, New York, USA, and colleagues and published in this week's PLoS Medicine.
Preeclampsia complicates 4%-5% of all pregnancies worldwide, causing significant maternal and neonatal mortality. Pregnancy in women with systemic lupus erythematosus (SLE) or the antiphospholipid syndrome (APS), two autoimmune diseases characterized by complement-mediated injury, is associated with an increased risk of preeclampsia.
Although further studies are needed to confirm and extend these findings, the results of this study suggest new genetic targets for the treatment of preeclampsia and raise the possibility of developing tests to identify women at risk of developing preeclampsia.
The authors conclude: "Our findings underscore the important role of complement activation in preeclampsia, define mutations and likely mechanisms for increased risk in patients with SLE and/or APS, and suggest new targets for treatment of this important public health problem that, thus far, has defied reliable prediction and satisfactory intervention."
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