May 16, 2011
New Mouse Model May Lead To New Therapies For Degenerative Diseases
Most degenerative diseases begin with a gradual loss of specific cell types that progresses, eventually leading to symptoms. For example, in type I diabetes, hyperglycemia commonly develops when approximately 80 percent of the beta cells in the pancreas are lost; in Parkinson's disease, motor dysfunction typically begins when neurons in a certain portion of the brain are decreased by 70 to 80 percent. Finding ways to stop early cell destruction is vital, but methods to do so have proven challenging because of limitations of models for early stages of cell loss.
A research team led by Albert Edge, Ph.D., principal investigator at the Massachusetts Eye and Ear Infirmary's Eaton-Peabody Laboratory and associate professor at Harvard Medical School, have engineered a new mouse that that can be used for research on degenerative disease. Their paper describing the findings, "Cre/lox mediated in vivo mosaic cell ablation to generate novel mouse models of degenerative disease," was published on May 16 in the Journal of Clinical Investigation.
"The mouse provides a way to study degenerative diseases and a model organism in which to develop therapies for those diseases," Dr. Edge said. "We targeted inner ear hair cells, beta cells in the pancreas, and epidermal cells. We found that whereas the beta cells and skin cells showed some regeneration in response to cellular loss, inner ear hair cells were not capable of regeneration and thus hair cell death caused partial deafness. The mouse will expedite our efforts to replace inner ear cells lost in deafness."
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