May 17, 2011
Cystic Fibrosis In Children: New Results
(Ivanhoe Newswire) "“ Contrary to previous research, a new study shows children with cystic fibrosis (CF) who have poor lung function early in life are more likely also to have poor lung function in adolescence, regardless of whether they are exposed to a common infection caused by the bacteria Pseudomonas aeruginosa in early childhood.
"We have shown that infection with Pseudomonas aeruginosa alone does not explain differences in lung function in early childhood that persist later in life," study author Jessica Pittman, MD, MPH, fellow in pediatric pulmonology at the University of North Carolina, Chapel Hill, was quoted as saying. "This implies that there may be other factors (including, perhaps, genetic, environmental, nutritional or inflammatory factors) acting during infancy and early childhood in children with CF that drive lung function in the school-age years and onwards.
"The results indicate that in these children, efforts to preserve lung function before age 6 are critical to maintaining good lung function into adolescence," Pittman said.
Children with low lung function at age 6 also had low lung function in adolescence, regardless of whether or not they had infection with P. aeruginosa in early childhood. Children with low lung function in early childhood also had a faster rate of decline in lung function from childhood to adolescence than those with better early childhood lung function.
The study also revealed that children with a higher body mass index (BMI) between the ages of 2 and 4 years had better lung function later in life than those with lower BMI. BMI is used to measure body fat; in this case, higher BMI indicated a better nutritional status.
"Our findings are in line with previous studies suggesting that CF lung disease begins in early childhood, and would suggest that further study needs to be done to identify causes of decline in lung function in infants and children with CF, in order to optimize management and improve the severity of illness and mortality," Dr. Pittman said. "This may also suggest that early intervention, whether it be preventing infections, improving nutrition or promoting clearance of excess mucus, may be beneficial in infants with CF."
Dr. Pittman noted that infection with P. aeruginosa in combination with other factors may be a cause of worsening lung disease in children with CF, and it may also be a marker of other factors leading to decline in lung function.
"We hope these studies will identify factors that can be targeted for further research and early intervention in order to improve lung function in children with CF both at an early age and later in life," Dr. Pittman said.
SOURCE: ATS 2011 International Conference, Denver, CO, May 13, 2011