June 29, 2011
HIV Drugs May Cause Premature Aging
(Ivanhoe Newswire) -- A class of anti-retroviral drugs commonly used to treat HIV, particularly in Africa and low income countries, can cause premature aging, according to this study. The study shows that the drugs damage DNA in the patient's mitochondria "“ the 'batteries' which power their cells.
The findings may explain why HIV-infected people treated with antiretroviral drugs sometimes show advanced signs of frailty and age-associated diseases such as cardiovascular disease and dementia at an early age.
Nucleoside analogue reverse-transcriptase inhibitors (NRTIs) were the first class of drug developed to treat HIV. They were a major breakthrough in the treatment of the disease, greatly extending lifespan and leading the condition to be seen as a chronic, rather than terminal, condition.
In high income countries, such as Europe and North America, the older NRTIs are used less commonly now due to concerns over toxicity and side-effects when taken over a long period of time. However, as they are now off-licence and hence relatively cheap, the drugs have proved to be an important lifeline for people infected with HIV in Africa and low income countries.
"HIV clinics were seeing patients who had otherwise been successfully treated but who showed signs of being much older than their years," Professor Patrick Chinnery, a Wellcome Senior Fellow in Clinical Science from the Institute of Genetic Medicine at Newcastle University, was quoted as saying.
"This was a real mystery. But colleagues recognised many similarities with patients affected by mitochondrial diseases "“ conditions that affect energy production in our cells "“ and referred them to our clinic."
Mitochondria are organelles in our cells which provide them with the energy to carry out their functions. During natural human aging, these mitochondria acquire mutations, though it is unclear whether these mutations are a cause of ageing or a consequence.
In an attempt to understand what was happening at a cellular level, Professor Chinnery and colleagues studied muscle cells from HIV-infected adults, some of whom had previously been given NRTIs.
The researchers found that patients who had been treated with NRTIs "“ even as long ago as a decade previously "“ had damaged mitochondria which resembled that of a healthy aged person.
The DNA in our mitochondria gets copied throughout our lifetimes and, as we age, naturally accumulates errors," Professor Chinnery said.
"We believe that these HIV drugs accelerate the rate at which these errors build up. So over the space of, say, ten years, a person's mitochondrial DNA may have accumulated the same amount of errors as a person who has naturally aged twenty or thirty years. What is surprising, though, is that patients who came off the medication many years ago may still be vulnerable to these changes."
SOURCE: Nature Genetics, published online June 26, 2011