July 22, 2011
Computer Simulations Aid Understanding Of Bacterial Resistance Against Commonly Used Antibiotics
A recent study into the interactions between aminoglycoside antibiotics and their target site in bacteria used computer simulations to elucidate this mechanism and thereby suggest drug modifications.
In the article, which will be published on July 21st in the open-access journal PLoS Computational Biology, researchers from University of Warsaw, Poland, and University of California San Diego, USA, describe their study of the physical basis of one bacterial resistance mechanism - mutations of the antibiotic target site, namely RNA of the bacterial ribosome. They performed simulations and observed changes in the interaction between the antibiotic and the target site when different mutations were introduced.
Bacteria have developed other ways of gaining resistance, not just through mutations, and further studies are underway. The authors are now investigating the resistance mechanism by which bacterial enzymes actively modify and neutralize aminoglycosidic antibiotics. These molecular modeling studies together with experiments could help to design even better aminoglycoside derivatives in the future.
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