August 5, 2011
Converting Human Cells into Brain Cells
(Ivanhoe Newswire) "“ A new method has been revealed to convert human cells into brain cells. By transforming adult skin cells into neurons that are capable of transmitting brain signals, scientist Sheng Ding, is marking one of the first documented experiments for transforming an adult human's skin cells into functioning brain cells.
"This work could have important ramifications for patients and families who suffer at the hands of neurodegenerative diseases such Alzheimer's, Parkinson's and Huntington's disease. Dr. Ding's latest research offers new hope for the process of developing medications for these diseases, as well as for the possibility of cell-replacement therapy to reduce the trauma of millions of people affected by these devastating and irreversible conditions," Lennart Mucke, M.D., director of neurological research at the Gladstone Institute of Neurological Disease, was quoted saying.
Dr. Ding used two genes and a microRNA to convert a skin sample from a 55-year-old woman directly into brain cells. MicroRNAs are tiny strands of genetic material that regulate almost every process in every cell of the body. The cells created by Dr. Ding's experiments exchanged the electrical impulses necessary for brain cells to communicate things such as thoughts and emotions. Using microRNA to reprogram cells is a safer and more efficient way than using the more common gene-modification approach. In following experiments, Dr. Ding hopes to rely only on microRNAs and pharmaceutical compounds to convert skin cells to brain cells, which should lead to a more efficient generation of cells for testing and regenerative purposes.
"This will help us avoid any genome modifications. These cells are not ready yet for transplantation. But this work removes some of the major technical hurdles to using reprogrammed cells to create transplant-ready cells for a host of diseases," Dr. Sheng Ding PhD, senior investigator at the Gladstone Institute of Cardiovascular Disease, was quoted saying.
SOURCE: Cell Stem Cell, August 4, 2011