August 30, 2005
Study Shows Genes May Affect Response to Different Quit-smoking Medications
(Philadelphia, PA) - A study by researchers at the Transdisciplinary Tobacco Use Research Center (TTURC) of the University of Pennsylvania School of Medicine indicates that a smoker's genetic make-up may affect whether they quit or not while using either bupropion (Zyban) or nicotine replacement therapies (NRTs) such as the nicotine patch or nasal spray. The results appear in the August issue of Neuropsychopharmacology.
"This study provides new evidence that genetic differences in the brain-reward pathways of smokers may reveal whether they would benefit more from ZybanÃ© or nicotine replacement therapy as an aid to quitting smoking," said lead author Professor Caryn Lerman, PhD, Director of the TTURC and Associate Director for Cancer Control Population Sciences at Penn's Abramson Cancer Center.
ZybanÃ©, as compared to smokers carrying the Del C variant. By contrast, smokers carrying the Del C variant had significantly higher quit rates if they used NRTs as compared to those with the Ins C variant. This research may have important implications for the delivery of quit-smoking medications that are targeted to individual smokers' needs. "Although these results require confirmation in a larger study prior to translation to practice," said Lerman, "they do suggest that genetic information may be useful in selecting the type of nicotine dependence treatment that will be most beneficial for a particular smoker."
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