November 1, 2005

Heart attack risk factors tied to kidney disease

NEW YORK (Reuters Health) - Diabetes is a major factor in
the development of chronic kidney disease, but among people
with poor blood sugar control who've not yet developed
diabetes, heart attack and stroke risk factors account for much
of their increased risk of developing kidney disease,
researchers report.

In the medical journal Diabetes, Dr. Caroline S. Fox of the
Framingham Heart Study, Massachusetts, and colleagues note that
it is unclear whether pre-diabetes is associated with chronic
kidney disease.

To investigate further, the researchers examined data on
almost 2400 participants in the Framingham Offspring Study who
attended an initial examination between 1991 and 1995 and a
follow-up examination between 1998 and 2001.

At the initial exam, 63 percent were normal, 29 percent
were on the path to becoming diabetic, 3.4 percent were just
diagnosed with diabetes and 4.6 percent had long-standing

At follow-up, 7 percent of the subjects had chronic kidney
disease. The rate increased as the initial blood sugar control

After factoring in risk factors for heart attack and
stroke, those with established diabetes had double the risk of
developing chronic kidney disease. However, subjects with newly
diagnosed diabetes and those with pre-diabetes did not have a
significantly increased risk.

Given the apparent influence of heart disease and stroke
risk factors, the researchers conclude that clinical trials are
warranted to see if their modification "can slow the decline in
kidney function in those with pre-diabetes."

SOURCE: Diabetes Care, October 2005.