Study: Lead Disrupts T-Cells in Mice

Although lead is a well-known human health hazard, University of Rochester scientists have found how lead harms T-cells in mice.

Researchers at the university’s medical center say they have discovered a new aspect of how lead might work in mice to harm T-cell functions, which regulate the body’s immune response to bacteria, viruses and other bugs.

The discovery adds insight to the latest trend in lead research, as scientists shift their emphasis from the immediate public health threat to understanding the long-term burden on the body, said Michael McCabe Jr., associate professor of environmental medicine.

We know more about lead than any other environmental agent, but we’re still trying to understand exactly why lead is dangerous and what its legacy might be, said McCabe.

Our research shows there may be additional long-term health threats, McCabe said. Lead appears to disrupt the immune system’s checks and balances, which must be in place if we are to successfully fight off pathogens. Our continuing research is aimed at discovering how lead upsets the balance of cells charged with protecting us.

The study recently appeared in the journal Toxicology and Applied Pharmacology.