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Cytori Therapeutics Demonstrates Adipose Stem Cells Improve Cardiac Function and Blood Flow in Preclinical Heart Attack Study; Data Presented at American Heart Association Scientific Sessions

Posted on: Wednesday, 16 November 2005, 03:02 CST

Cytori Therapeutics, Inc. (Frankfurt:XMPA), today presented results demonstrating that adipose-derived adult stem and regenerative cells improved blood flow to the site of injury in a preclinical model of a severe heart attack. These data demonstrate a significant increase in capillary density, a measure of the amount of oxygenated blood supplied to surrounding tissue, and support previously reported results that adipose-derived adult stem and regenerative cells enhance cardiac function. The results of the study were presented at the American Heart Association Scientific Sessions 2005 in Dallas, TX. (abstract no. 1386).

In a randomized study, autologous adipose stem and regenerative cells (treated) or saline (control) were delivered into the left ventricular chamber, an approximation of intracoronary delivery. After twelve weeks, the capillary density in the treated group was greater than 40% than in the control group at the border zone, the site immediately adjacent to the injury. Capillary density is recognized as a measure of the quality of tissue perfusion and has been shown to decrease significantly in border zone following a heart attack. Increased perfusion helps to reduce progression of a heart attack into more severe cardiovascular disease.

"These results are consistent with our previously reported data, which demonstrate the ability of adipose stem and regenerative cells to improve cardiac function by enhancing multiple healing mechanisms, including the formation of new blood vessels to damaged heart tissue," said Marc H. Hedrick, M.D., President for Cytori Therapeutics. "Furthermore, this preclinical study illustrates the significant therapeutic potential of adipose-derived stem and regenerative cells in ischemic heart disease for which we expect to initiate European clinical studies next year."

Adipose tissue, also known as fat, is an abundant source of stem cells and other regenerative cells that can contribute to the repair and healing of damaged tissue. These cells have been shown to reduce the extent of a heart attack and promote restoration of heart function by a variety of mechanisms, including promotion of blood vessel growth and differentiation into cardiac muscle tissue.

About Cytori Therapeutics

Cytori Therapeutics (Frankfurt:XMPA) is discovering and developing proprietary cell-based therapeutics utilizing adult stem cells derived from adipose tissue, also known as fat. The Company's investigational therapies target cardiovascular disease, spine and orthopedic conditions, gastrointestinal disorders and new approaches for aesthetic and reconstructive surgery. To facilitate processing and delivery of adipose stem cells, Cytori is developing its proprietary Celution(TM) system to isolate and concentrate a patient's own stem cells in about an hour. This system will dramatically improve the speed in which personalized cell-based therapies can be delivered to patients.

Cautionary Statement Regarding Forward-Looking Statements

This press release includes forward-looking statements regarding events and trends which may affect Cytori Therapeutics' future operating results, cell therapy product development, and financial position. Such statements are subject to risks and uncertainties that could cause the Company's actual results, product development timelines, and financial position to differ materially. Some of these risks and uncertainties are described (under the heading "Risk Factors") in Cytori Therapeutics' 2004 Form 10-K annual report for the year ended December 31, 2004 and subsequent SEC filings, which are available through the Company's web site. Cytori Therapeutics assumes no responsibility to update any revision of forward-looking statements to reflect events, trends or circumstances after the date they are made.

Source: Business Wire

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