Heart Burn Medications Are Risk Factors
Posted on: Tuesday, 20 December 2005, 18:00 CST
Montreal researchers have discovered drugs that reduce gastric acidity are potential risk factors for Clostridium difficile infection outside of hospitals.
The study on community-acquired C. difficile is a follow-up to previous work by the McGill University Health Center scientists that demonstrated an increased risk from drugs such as heart burn medications in hospital settings.
We believe drugs that reduce gastric acidity provide a more hospitable environment within which C. difficile bacteria can colonize, said Dr. Sandra Dial, a MUHC researcher and lead author of the new study. Numerous studies worldwide have documented increases in hospital C. difficile associated disease, but the MUHC study is the first to suggest the trend is mirrored in the general community.
Using data from the United Kingdom General Practice Research Database, the researchers traced variation in community C. difficile associated disease over a 10-year period. In 1994 there was less than one C. difficile case per 100,000 people in the database, says Dial. By 2004, this number had increased exponentially to 22 cases to per 100,000.
The research appears in the Journal of the American Medical Association.
Source: United Press International
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