Stomach bacteria linked to iron deficiency

By Anthony J. Brown, MD

NEW YORK (Reuters Health) – Helicobacter pylori infection,
which affects about one third of adults in the US, is
associated with an increased risk of iron deficiency and
related anemia, according to the results of a new study.

Moreover, this relationship holds true even in the absence
of peptic ulcer disease, which can cause iron-deficiency anemia
through hemorrhage, the researchers report in the American
Journal of Epidemiology.

“For the first time in a national sample of the US
population, we found an apparent link between H. pylori
infection and iron deficiency” and iron-deficiency anemia, lead
author Dr. Victor M. Cardenas, from the University of Texas at
Houston, told Reuters Health.

H. pylori infection has previously been found to cause
stomach inflammation and most ulcers. The bacterium also
increases the risk of stomach cancer.

The researchers identified this new relationship based on
an analysis of data from the current National Health and
Nutrition Examination Survey (1999-2000). Data on 7,462
subjects who were at least three years of age were included in
the analysis.

The presence of H. pylori infection raised the risk of iron
deficiency and iron-deficiency anemia by 1.4- and 2.6-fold,
respectively. H. pylori infection was also tied to other types
of anemia, but to a much lesser extent.

How might H. pylori infection promote iron deficiency short
of causing a bleeding ulcer? “The rapid turnover of H. pylori,
which seems to sequester iron, is one possible mechanism,”
Cardenas said.

He added that his group is now seeking funding for a
randomized trial to see if eradication of H. pylori can improve
iron deficiency in children.

SOURCE: American Journal of Epidemiology, January 15, 2006.