Critical Therapeutics to Announce First-Quarter 2006 Financial Results on May 4

Critical Therapeutics, Inc. (NASDAQ: CRTX), a biopharmaceutical company engaged in the discovery, development and commercialization of products for respiratory, inflammatory and critical care diseases, will conduct a conference call at 5:00 p.m. ET Thursday, May 4, following the after-market release of its first-quarter 2006 financial results. Critical Therapeutics President and Chief Executive Officer Paul Rubin, M.D. will lead the call, during which senior management will discuss the Company’s first-quarter financial results, additional corporate activities and upcoming milestones.

Investors and others are invited to listen live via telephone or the Internet.

 What:          Critical Therapeutics First-Quarter 2006 Financial                Results Conference Call  When:          5:00 p.m. ET Thursday, May 4, 2006  Dial-in:       From the U.S. and Canada, dial (800) 406-5345                International callers, dial (913) 981-5571  Confirmation Code:          7161304  Webcast:       Visit www.crtx.com, go to the “Investors” page and then                click on the conference call link about five minutes                before the call. 

To access the replay, visit www.crtx.com, click on “Investors” and then on “Webcasts & Presentations.”

About Critical Therapeutics

Critical Therapeutics, Inc. is a biopharmaceutical company focused on the discovery, development and commercialization of products for respiratory, inflammatory and critical care diseases. The Company owns worldwide rights to the asthma drug ZYFLO(R) (zileuton tablets), as well as other formulations of zileuton. ZYFLO is the only 5-lipoxygenase inhibitor approved for marketing by the U.S. Food and Drug Administration. The Company’s commercialization efforts for ZYFLO are carried out by its 80-person specialty sales force. Critical Therapeutics also is developing treatments directed toward the severe inflammatory response in acute diseases and conditions that lead to admission to the emergency room or intensive care unit, and acute exacerbations of other chronic diseases that frequently lead to hospitalization. For more information, please visit www.crtx.com.