Exercise, Diet May Reduce Colon Polyps
Posted on: Monday, 15 May 2006, 15:03 CDT
Voluntary exercise and a restricted diet cut the number and size of polyps in the intestines of male mice and improved survival, finds a U.S. study.
The study, in the journal Carcinogenesis, is the first to suggest that a negative energy balance produced by increasing the mice's energy output by use of a running wheel while maintaining a restricted calorie intake appeared to be the important factor in inhibiting the growth of polyps.
Polyps are the forerunners of colorectal tumors, says lead author Lisa H. Colbert, assistant professor at the University of Wisconsin-Madison.
Our studies are relevant for humans in that these mice have a mutation in one of the same genes, APC, that is also mutated in human colon cancer, Colbert explains. The protective effect of exercise and lower body weight in our mice is consistent with epidemiological evidence in humans that suggests higher levels of activity and lower body weight reduces the risk of colon cancer.
Source: United Press International
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