May 22, 2006
Botox effective for overactive bladder: study
NEW YORK (Reuters) - The popular wrinkle treatment Botox
may have more than just cosmetic applications for people with a
far more pressing quality of life issue than a wish to present
an unfurrowed brow in public.
Botox, or botulinum-A toxin, was highly effective in
treating patients with severe overactive bladder in a clinical
trial and the desired effect lasted for months, according to
results presented by researchers at a medical conference in
Atlanta on Sunday.
Allergan Inc., which sells Botox, did not sponsor the
study, which was conducted independently by researchers in
urology. But an Allergan spokeswoman said the company has been
"seeing very positive and encouraging trends" in the use of
Botox for overactive bladder in its own clinical studies.
She said Allergan was proceeding with enrollment in mid-
and late-stage clinical trials of the drug as a treatment for
the disorder, but does not expect to see it gain U.S. approval
for that use until 2010.
In the study of 150 patients suffering from severe
overactive bladder, 88 percent of those injected with Botox
showed a statistically significant improvement in bladder
function, researchers concluded.
Urgency to urinate completely disappeared in 76 percent of
patients and incontinence disappeared in 82 percent within two
weeks, according to the results.
Patients suffering from overactive bladder received 100 IU
of Botox injected into the detrusor, the muscle that controls
Effectiveness of duration was a mean 9 months and after 11
months 23 percent of patients were reinjected after the desired
effect had diminished, researchers said.