May 30, 2006

Concentrated radiotherapy effective for breast cancer

LONDON (Reuters) - Fewer but more concentrated doses of
radiotherapy could be as safe and effective as a longer course
of treatment for breast cancer patients, researchers said on

Women having radiotherapy, which is given to reduce the
risk of the cancer returning after surgery, normally receive 25
doses over five weeks.

But a 10-year trial of a shorter course of 13 larger doses
showed it worked just as well as the standard treatment and
without an increase in side effects.

"We think it should be possible to give fewer but higher
daily doses of radiotherapy to the breast to prevent cancer
from returning, without harming the patient's healthy tissues,"
said Professor John Yarnold of the Institute of Cancer Research
and the Royal Marsden NHS Foundation Trust.

Yarnold and his team, who reported their findings in the
journal Lancet Oncology, compared the shorter dose of
radiotherapy with the standard treatment on 1,410 women who had
radiotherapy following surgery.

After monitoring their health for 10 years, they found the
shorter course was as good as the extended treatment.

But the researchers added they will have to wait for the
results of other trials before they can confirm that the
concentrated therapy is more effective in the long term.

The shorter treatment would be more convenient and simpler
for patients and could also cut healthcare costs for
administering the treatment.

"If these results are confirmed in the larger follow-up
studies, it could mean better outcomes with less hospital
visits for patients and therefore an improvement in their
quality of life," said Dr Lesley Walker of the charity Cancer
Research UK.

Breast cancer is one of the most common cancers in women.
More than a million cases occur worldwide each year, according
to the International Agency for Research on Cancer (IARC) in
Lyon, France.

Most cases develop in women over 50 years old but a small
percentage occurs in younger women.

Breast cancer is treated with surgery and radiotherapy,
which kills cancer cells left in the breast after the tumour
has been removed, chemotherapy and hormone treatment, or a
combination of them, depending on the cancer and stage of the

Factors which can increase a woman's risk of the breast
cancer include having a mother or close relative with the
disease, inherited mutations in the BRCA1 or BRCA2 genes, an
early puberty, late menopause and not having any children.