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Testosterone adds to estrogen's cancer risk: study

Posted on: Monday, 24 July 2006, 15:04 CDT

CHICAGO (Reuters) - Women seeking relief from menopausal symptoms and diminished sex drive by taking testosterone as well as estrogen face a higher risk of breast cancer than with estrogen alone, a study said on Monday.

Hormone replacement therapy often helps relieve debilitating symptoms of menopause such as hot flashes, night sweats and vaginal dryness. But since 2002, when a large study found an association with higher risks of breast cancer, strokes and blood clots, many women stopped taking hormone therapy or were advised to keep their dosage as low as possible and to stop using it as quickly as possible.

Analyzing data on more than 120,000 women in the Nurses' Health Study, researchers from Boston's Brigham and Women's Hospital and Harvard Medical School found the more than 800 women who had taken estrogen with testosterone -- which is targeted at boosting depressed mood and sex drive and lessen bone deterioration -- faced an even higher risk of breast cancer.

The combination of estrogen and testosterone raised the risk of developing breast cancer by 77 percent compared to women not taking hormones. Estrogen therapy alone carried a 15 percent higher risk and estrogen combined with progesterone -- taken to cut the attendant risk of ovarian cancer -- carried a 58 percent higher risk.

"Although post-menopausal therapies may provide improvement with respect to sexual functioning, general well-being and bone health, the increased risk of breast cancer may outweigh these benefits," study author Rulla Tamimi wrote in the Archives of Internal Medicine.

For menopausal women seeking alternatives to hormone replacement therapy, the news was also not good.

A review of 70 studies of alternative therapies that ranged from protein diets to meditation found insufficient evidence to recommend any of them. However the so-called placebo effect made as many as half the participants feel better.

A majority of the studies examined vitamins, proteins, complete diets or other biologically based treatments; some focused on mind-body therapies, including meditation and guided imagery; one studied osteopathic manipulation; two looked at reflexology and magnet therapy treatments; and others assessed traditional Chinese medicine or Indian ayurvedic medicine.

Of 15 studies of women taking soy-derived phytoestrogens, participants in four indicated they got relief from menopausal symptoms; the shrub cohosh was helpful to women in one study, but not in three others; and mind-body therapies were found to be of little help.

More rigorous studies of these therapies are needed since many of the women trying alternatives to hormones do so without informing their doctors, study author Dr. Anne Nedrow of Oregon Health and Science University, Portland, wrote in the journal.

Source: REUTERS

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