Takeda's Actos Reduces Stroke Risk in Diabetes Study
Posted on: Monday, 4 September 2006, 09:00 CDT
A trial of Takeda's oral antidiabetic Actos has shown the drug to be capable of significantly reducing the incidence of stroke by almost 50% in high-risk patients with type 2 diabetes.
New analyses from the landmark PROactive study examined the effects of Actos on the risk of stroke and other cardiovascular outcomes in high-risk patients with type 2 diabetes, with and without prior stroke. Pre-specified study endpoints included all-stroke and cardiovascular disease death, myocardial infarction (MI) or stroke.
According to the results, there were statistically significant benefits of Actos in patients who had suffered a prior stroke. The incidence of recurrent stroke was reduced by 47% and the combined risk of death, MI or stroke was reduced by 28%.
There was no effect of Actos on subsequent strokes in patients who had never experienced a stroke.
"These results are very encouraging news for people with type 2 diabetes because they demonstrated that Actos reduced the incidence of strokes in patients who had already experienced a stroke from 10.2% down to 5.6 %, translating to a risk reduction of almost 50%," said Robert Wilcox, professor in the department of cardiovascular medicine at University Hospital, Nottingham, UK.
Source: Datamonitor
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