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Bruker Daltonics and Isis Pharmaceuticals Announce the European Introduction of the Ibis T5000 Biosensor System

Posted on: Monday, 25 September 2006, 00:00 CDT

At the 9th International Conference in Genomics and Proteomics of Human Pathogens in London, UK, Bruker Daltonics Inc. and Isis Pharmaceuticals, Inc. today announced the European introduction of the Ibis T5000(TM) biosensor system for the identification and characterization of microorganisms. The Ibis T5000 system is an automated biosensor for healthcare research applications, which enables the analysis of viruses, bacteria, and fungi without any microbial culturing or genome sequencing steps. The Ibis T5000 relies on technology and applications developed by Ibis Biosciences(TM), a division of Isis Pharmaceuticals, incorporating Bruker Daltonics' proven micrOTOF(TM) ESI TOF mass spectrometer.

Following the announcement of a manufacturing and distribution agreement between Isis Pharmaceuticals and Bruker Daltonics earlier this year, the companies have taken the next important step towards commercialization of the Ibis T5000 biosensor system by entering the large European markets. Ready-to-use consumable assay kits will be available for applications such as pan-influenza surveillance (human and avian) and detection of sources of hospital-associated infections, including methicillin-resistant Staph. aureus (MRSA) strains. Applications will also enable in depth characterization of bacterial strain types, antibiotic resistance profiles and virulence markers. The Ibis T5000 is currently designated for Research Use Only (RUO).

Michael Treble, President of the Ibis Biosciences division and Vice President of Isis Pharmaceuticals, commented, "We're excited about the European introduction of the Ibis T5000 biosensor system, which has the potential to revolutionize infectious microorganism detection. And we're especially pleased that our partner, Bruker Daltonics, will be manufacturing, installing and servicing the Ibis T5000 instruments. Bruker has an extensive global infrastructure to support customers at the point of use, enabling Ibis to focus on the development, manufacture and supply of reagent kits."

Wolfgang Pusch, Assistant Vice President for Clinical Research Solutions of Bruker Daltonics, stated: "The Ibis T5000 biosensor system analyzes the DNA of infectious disease microorganisms, and is an ideal complement to Bruker Daltonics' existing MALDI BioTyper(TM) platform for microorganism identification based on protein signatures. With the Ibis T5000 we further expand the scope of our products in microbiology and can now even address applications as important as hospital-associated infections and influenza surveillance. This is a further milestone in establishing Bruker Daltonics as the leading supplier for mass spectrometry-based systems for clinical research, including infectious disease research and epidemiology."

ABOUT ISIS PHARMACEUTICALS, INC.

Isis is exploiting its expertise in RNA to discover and develop novel drugs for its product pipeline and for its partners. The Company has successfully commercialized the world's first antisense drug and has 15 drugs in development. Isis' drug development programs are aimed at treating cardiovascular, metabolic and inflammatory diseases. Isis' partners are focused in disease areas such as inflammatory, ocular, viral and neurodegenerative diseases, and cancer. In its Ibis division, Isis is developing and commercializing the Ibis T5000 biosensor system, a revolutionary system to identify infectious organisms. As an innovator in RNA-based drug discovery and development, Isis is the owner or exclusive licensee of approximately 1,500 issued patents worldwide. Additional information about Isis is available at www.isispharm.com.

ABOUT BRUKER BIOSCIENCES

Bruker BioSciences Corporation in Billerica, Massachusetts is the parent company of Bruker AXS Inc., Bruker Daltonics Inc. and Bruker Optics, Inc. Bruker AXS is a leading developer and provider of life science, materials research and industrial X-ray analysis tools. Bruker Daltonics is a leading developer and provider of innovative life science tools based on mass spectrometry, and also offers a broad line of nuclear, biological and chemical (NBC) detection products for homeland security. Bruker Optics is a leading developer, manufacturer and provider of research, analytical and process analysis instruments and solutions based on infrared and Raman molecular spectroscopy technology. For more information, please visit www.bruker-biosciences.com

CAUTIONARY STATEMENT OF ISIS PHARMACEUTICALS AND BRUKER BIOSCIENCES

This press release includes forward-looking statements regarding commercialization of the Ibis T5000 biosensor system and related products, as well as both companies' plans and goals for the alliance. Any statement describing Isis' or Bruker's goals, expectations, intentions or beliefs is a forward-looking statement and should be considered an at-risk statement. Such statements are subject to certain risks and uncertainties, particularly those inherent in developing and commercializing systems to identify infectious organisms that are effective and commercially attractive, and in the endeavor of building a business around such products. Isis' and Bruker's forward-looking statements also involve assumptions that, if they never materialize or prove correct, could cause its results to differ materially from those expressed or implied by such forward-looking statements. Although Isis' and Bruker's forward-looking statements reflect the good faith judgment of its management, these statements are based only on facts and factors currently known by Isis and Bruker. As a result, you are cautioned not to rely on these forward-looking statements. These and other risks are described in additional detail in Isis' and Bruker's respective annual reports on Form 10-K for the year ended December 31, 2005, and their respective quarterly reports on Form 10-Q for the quarter ended June 30, 2006, which are on file with the SEC. Copies of these and other documents are available from the companies.

Ibis Biosciences(TM) is a trademark of Isis Pharmaceuticals, Inc.

Ibis T5000(TM) is a trademark of Isis Pharmaceuticals, Inc.

micrOTOF(TM) is a trademark of Bruker Daltonics Inc.

MALDI BioTyper(TM) is a trademark of Bruker Daltonics Inc.

Source: Business Wire

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