Scientists Explore Bone Marrow Disease
Posted on: Monday, 9 October 2006, 18:00 CDT
U.S. researchers say they've discovered a molecular mechanism underlying bone marrow failure in the X-linked human disease dyskeratosis congenital.
DC is a rare, progressive bond marrow failure syndrome that is fatal early in life.
But Drs. Judy Wong and Kathleen Collins at the University of California-Berkeley, working with cells derived from DC patients, have demonstrated X-linked DC cells are unable to renew themselves because they cannot maintain sufficiently long telomeres to support proliferation.
The researchers say they found those defects in telomere maintenance are caused by a reduction in telomerase RNA, rather than a deficiency in ribosome biogenesis, as some other groups have hypothesized.
Collins said she is hopeful our studies to understand disease mechanism will aid ongoing clinical efforts to develop disease therapies.
The research appears in the Oct. 15 issue of the journal Genes & Development.
Source: United Press International
Related Articles
- Microbiology Profile in Women With Pelvic Inflammatory Disease in Relation to IUD Use
- Pelvic Inflammatory Disease During the Post-Partum Year
- A Chlorotic Spot Disease on Calla Lilies (Zantedeschia Spp.) Is Caused By a Tospovirus Serologically but Distantly Related to Watermelon Silver Mottle Virus
- Disease Notes: March 3, 2005
- A New Link to Parkinson's Disease
- Artist's Skills Blossom After Brain Disease
- Alcohol Doesn't Protect Against Parkinson's Disease
- Beating Odds of Heart Disease, Stroke in Diabetics
- Alzheimer's Disease
- Addison's Disease
 |
 |
User Comments (0)
RSS Feeds