Early Onset of Cystic Fibrosis Studied
Posted on: Wednesday, 2 May 2007, 12:00 CDT
A French study of children with cystic fibrosis has found evidence of very early onset defective bone mineralization in the lumbar spine.
A study by researchers at the Necker Hospital for Sick Children in Paris found the condition in the part of the lumbar spine -- located between the ribs and the pelvis -- was not caused by either nutritional status or lung disease in children between 2 years and puberty.
Dr. Isabelle Sermet-Gaudelus and colleagues studied 25 children with cystic fibrosis younger than 6, 53 pre-pubertal children ages 6 to 10, and 36 adolescents 11 to 18.
They found ideal weight for height, fat-free mass and fat mass values decreased significantly as the children aged. Also, pulmonary disease severity increased significantly, mainly in adolescents.
The researchers recommend all children with CF undergo assessment of bone mineral density and body composition early in life to target those who need preventive treatment.
Efforts to obtain and maintain normal bone status in these children must begin early in childhood, said Sermet-Gaudelus.
The study appears in the American Journal of Respiratory and Critical Care Medicine.
Source: United Press International
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