Signs and Symptoms of Marfan Syndrome

Marfan Syndrome is usually genetic, but it can also be caused by mutations in the connective tissue that delivers nutrients to cells. It affects people of all ages and races.

People with the disorder are usually tall, thin and loose jointed. They may have longer-than-normal extremities, a curved backbone, and a concave or protruding breastbone.

Symptoms include a variety of mild-to-severe health problems involving the bones, heart and blood vessels, eyes, skin, nervous system and lungs. The heart may have a weakened aorta or a leaky valve. Eye problems include nearsightedness, glaucoma, cataracts and detached retinas.

The nervous system may be affected by a fluid and membrane covering on the brain and spinal cord causing abdominal or leg pain. Lungs may collapse.

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