July 1, 2012
Bees Have A Sweet Tooth Too
redOrbit Staff & Wire Reports - Your Universe Online
According to scientists at Arizona State University, honey bees may hold clues to human taste perception and metabolic disorders.
Gro Amdam, an associate professor, and Ying Wang, a research scientist, in the School of Life Sciences in ASU´s College of Liberal Arts and Sciences conducted genetic tests on honey bees and identified connections between sugar sensitivity, diabetic physiology and carbohydrate metabolism. Bees and humans may in part share these associations.
The study, published in the open-access journal PLoS Genetics, explains how for the first time, two genes in the bees´ “master regulator” module that controls food-related behaviors were successfully turned off. By accomplishing this, researchers discovered a possible molecular link between sweet taste perception and the state of internal energy.
“A bee´s sensitivity to sugar reveals her attitude towards food, how old the bee is when she starts searching for nectar and pollen, and which kind of food she prefers to collect,” said Wang, the lead author of the paper. “By suppressing these two ℠master´ genes, we discovered that bees can become more sensitive to sweet taste. But interestingly, those bees also had very high blood sugar levels, and low levels of insulin, much like people who have Type 1 diabetes.”
In Amdam´s honey bee lab at ASU, scientists suppressed two genes including vitellogenin, which is similar to a human gene called apolipoprotein B, and ultraspiracle, which associates with an insect hormone that has some functions in common with the human thyroid hormone. The team is the first in the world to accomplish this double gene-suppressing technique. Researchers used this method to understand how the master regulator works.
“Now, if one can use the bees to understand how taste perception and metabolic syndromes are connected, it´s a very useful tool,” said Amdam, who also has a honey bee laboratory at the Norwegian University of Life Sciences. “Most of what we know about deficits in human perceptions is from people who are very sick or have had a brain trauma. We know shockingly little about people in this area.”
The researchers are now taking into account how, exactly, the bees´ sweet taste was enhanced by the experiment. The most metabolically active tissue of the bee, called the fat body, may hold the key. The fat body is similar to the liver and abdominal fat in humans, in that it helps store nutrients and creates energy.
Amdam explains that taste perception evolved as a survival mechanism, for bees as well as for people. For example, bitter foods may be poisonous or sweet taste may signal foods rich in calories for energy. For all animals, taste perception must be in touch with one´s internal energetic state to control food intake and maintain normal life functions. Without this, poorly functioning taste perception can contribute to unhealthy eating behaviors and metabolic diseases, such as diabetes and obesity.
“From this study, we realized we can take advantage of honey bees in understanding how food-related behaviors interact with internal metabolism, as well as how to manipulate these food-related behaviors in order to control metabolic disorders,” added Amdam