How Do Tumor Cells Create Their Own Pathways
Potential new treatment for metastatic colon cancer
How does a tumor cell set up a signaling pathway in order to metastasize? Scientists at Technische UniversitÃ¤t MÃ¼nchen’s (TUM) Klinikum rechts der Isar and Helmholtz Zentrum MÃ¼nchen have made a significant discovery in this area by studying colon cancer. They have learned that the tumor cells release certain proteins known as chemokines. In the case of metastatic colon cancer cells, the chemokine concerned is CCL2. The CCL2 chemokine docks on to the cells of the inner blood vessel walls (endothelial cells) and activates the corresponding receptor (CCR2 receptor). This connection makes the endothelial cells permeable — creating a clear path for the tumor cells.
Professor Mathias HeikenwÃ¤lder of TUM’s Institute of Virology explains that the tumor cells use a clever trick to migrate: “The tumor cells outwit the endothelial cells by emitting a signal used by healthy cells.” To date, research has mainly focused on macrophage cells attracted by the chemokines of the tumors. “By understanding the role of chemokine receptors in relation to endothelial cells we have potentially uncovered a brand new approach to cancer treatment,” says HeikenwÃ¤lder.
“Measuring the number of chemokines could allow us to draw clear conclusions on the likely spread of a primary tumor to other organs and predict the risk of metastasis in patients,” continues HeikenwÃ¤lder. “Furthermore, the option of blocking the chemokine receptor CCR2 at the endothelial cells gives healthcare professionals a new way of preventing metastases both before and following an operation.”
For their research, the scientists used colon cancer tissue and colon cancer cell lines from mice and humans. The next steps will involve studying the findings in greater detail and examining how the new concept can be transferred to other types of cancer.
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