February 20, 2013
Insight Into Tissue Regeneration Offered From Newt Transcriptome
Scientists have identified protein families expressed during tissue regeneration in newts, providing the groundwork for research into whether particular sets of genes are used for the purpose. The transcriptome — the map of all RNA molecules — of the newt is published this week in BioMed Central's open access journal Genome Biology. Notophthalmus viridescens is a useful model in regenerative medicine, thanks to its ability to regenerate tissue, and this data gives insights into the mechanisms behind this process.
The transcriptome is not complete, but serves as a matrix for further analyses. The authors believe that their findings represent only the tip of the iceberg: 'Our data provide the groundwork for mechanistic experiments to answer the question whether urodeles utilize proprietary sets of genes for tissue regeneration.' They continue: 'The newly established de novo transcriptome [...] will be an indispensable resource for a better understanding of regenerative events in newts and facilitate the identifications of molecules [...] that control this fascinating process.'
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