September 18, 2013
Inner Workings Of Cancer Uncovered By Capturing Live Images Of Growing Tumors
The Optical Society
New technology presented at OSA's Frontiers in Optics meeting will help fight cancer
These techniques, created by Fukumura and his long-term collaborators at Massachusetts General Hospital and Harvard Medical School, combine two different high-tech optical imaging methods that were custom-built for the research. One is called multiphoton laser-scanning microscopy (MPLSM), which is an advanced fluorescence imaging technology that is now commercially available at the high end of the microscope market. The other is called optical frequency domain imaging (OFDI), which images tissues by their light scattering properties. According to Fukumura, OFDI is gaining popularity in the optical imaging field but has yet to become commercially available.
"MPLSM overcomes many of the limitations from which conventional microscopy and confocal microscopy suffer, and OFDI provides robust large volume imaging data," Fukumura said.
Fukumura will present their research at FiO 2013, taking place Oct. 6-10 in Orlando, Fla. There, he will describe how his unique technique can image tumors inside and out, and show detailed pictures of live tumors—images that he and colleagues call "astonishing."
He added that while the new combined approach would be too expensive to be used for routine diagnostic purposes, it promises to help researchers better understand the intricate workings of human cancer and aid in drug discovery to treat cancer. "These optical imaging approaches can provide unprecedented insights in the biology and mechanisms of cancer," he said.
Presentation FW5A.2, "Experimental Methods for In Vivo Tissue Imaging," takes place Wednesday, Oct. 9 at 4:15 p.m. EDT at the Bonnet Creek Ballroom, Salon IV at the Hilton Bonnet Creek in Orlando, Fla.
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