December 5, 2013
Pulsatile Blood Flow Uncovers New Migraine Features
University of Eastern Finland
With every heartbeat, the blood is sent to all our peripheral tissues, generating changes in pulsatile perfusion. Using these pulsatile changes as a source of information, researchers at the University of Eastern Finland have developed a new method of 2D mapping of microcirculation, called BPI (Blood Pulsation Imaging). The aim is to use the pulsatile vascular changes detected with BPI for diagnostic purposes.
The research consortium comprising physicists, physiologists and neurobiologists was coordinated by Professor Rashid Giniatullin at A. I. Virtanen Institute. In two recent articles published in PLOS ONE they described new vascular phenomena detected with the BPI technique. One of these studies found that there are so-called 'hot spots' with high amplitude of pulsatile changes which reflect high variability of microcirculation detected by this technique (Kamshilin et al., 2013). The other study showed that there are transverse blood pulsation waves in the faces of migraine patients, whereas in healthy people such waves are symmetrical as shown in the figure below (Zaproudina et al., 2013). The latter finding was received with excitement by specialists, as was evidenced from the feedback of the recent lecture of R. Giniatullin at Scandinavian Pain Conference in Helsinki.
This discovery demonstrated a major difference in the timing of lateralized blood supply (asynchronous supply) to the faces of healthy individuals and migraine sufferers. The main focus of Professor Giniatullin's research group are cellular and molecular mechanisms of migraine in animal models, but their recent discoveries made in human beings are creating a bridge between fundamental and clinical migraine studies by opening new perspectives for prediction, diagnosis and, likely, for monitoring the efficiency of anti-migraine medicines.
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