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This Book Takes Account Of The Shifting Perspective In The Study Of Cellular Energetics For The First Time Addressing Energy Metabolism On A Systems Biology Level

Posted on: Thursday, 15 November 2007, 09:00 CST

Research and Markets (http://www.researchandmarkets.com/reports/c74416) has announced the addition of "Molecular System Bioenergetics: Energy for Life" to their offering.

The book takes account of the shifting perspective in the study of cellular energetics, for the first time addressing energy metabolism on a systems biology level. It includes a brief review of classical bioenergetics, but its main focus is on recent approaches to study systems bioenergetics, both on the cellular and on the organ level. Novel concepts of metabolite channelling and of metabolons are introduced. A large part is devoted to metabolic signalling and its pathological implications, e. g. in the so-called metabolic syndrome. The final part of the book describes the application of systems bioenergetics to the study of cancer, cell death and other medically important processes.

In this first integrated view, practically each of the world's leading experts has contributed to this one and only authoritative resource on the topic. Bringing systems biology to cellular energetics, they address in detail such novel concepts as metabolite channelling and medical aspects of metabolic syndrome and cancer.

About the author:

Valdur Saks is Professor of Bioenergetics and Biochemistry at the University of Grenoble, France, and Head of the Laboratory of Bioenergetics at the National Institute of Chemical and Biological Physics in Tallinn, Estonia. A graduate of Moscow University, he was the long-time head of the Laboratory of Cardiac Bioenergetics in Moscow, Russia, before taking up his present positions. Professor Saks has authored over 220 scientific publications and has received numerous scientific awards, including the USSR State Prize in Science and the International "Research and Development" Award sponsored by the U.N. and UNICEF. He is a member of the International Society for Heart Research and of the American Physiological and Biophysical Societies.

Contents:

Introduction

MOLECULAR SYSTEM BIOENERGETICS: BASIC PRINCIPLES, ORGANISATION AND DYNAMICS OF CELLULAR ENERGETICS

Cellular Energy Metabolism and Integrated Oxidative Phosphorylation

Organization and Regulation of Mitochondrial Oxidative Phosphorylation

Integrated and Organized Cellular Energetic Systems: Theories of Cell Energetics, Compartmentation and Metabolic Channelling

On the Network Properties of Mitochondria

Structural Organization and Dynamics of Mitochondria in the Cells In Vivo

ENERGY TRANSFER NETWORKS, METABOLIC FEEDBACK REGULATION AND MODELING OF CELLULAR ENERGETICS

Mitochondrial VDAC and its Complexes

Phospho-Creatine Circuit: Integration of Adenylate Kinase, Glycolytic and Glycogenolytic Circuits in Cellular Energetics

Signalling by AMP-Activated Protein Kinase

Developmental and Functional Consequences of Disturbed Energetic Communication in Brain of Creatine Kinase Deficient Mice

System Analysis of Cardiac Energetics - Excitation-Contraction Coupling

Principles of Mathematical Modelling and In Silico Studies of Integrated Systems of Cellular Energetics

Modelling Energetics of Ion Transport, Membrane Sensing and System Biology of the Heart

APPLIED MOLECULAR SYSTEM BIOENERGETICS

Mitochondrial Adaptation to Exercise and Training - A Physiological Approach

Mitochondrial Medicine: The Central Role of Cellular Energetic Depression and Mitochondria in Cell Pathophysiology

Tumour Cell Energetic Metabolome

AMPK and the Metabolic Syndrome

A Systems Biology Perspective of Obesity and Type 2 Diabetes

For more information visit http://www.researchandmarkets.com/reports/c74416

Source: Business Wire

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