New Way Found to Map Controller Proteins
Posted on: Tuesday, 28 December 2004, 15:00 CST
U.S. scientists said they can map all sites on the human genome regulated by a particular protein, which could speed development of new disease treatments.
The new technique examined one of the body's many transcription factors, molecules that increase or decrease the level of gene expression in a cell. Discovering ways to rapidly map the DNA affected by different transcription factors could lead to better ways to treat diseases linked to transcription glitches.
The new technique involves linking the transcription factor with DNA and isolating the resulting molecule. Strips of short DNA, called genomic signature tags, are released by the molecule. The results are then identified in the international genome database.
The research team reported it has uncovered about 6,300 regulatory regions that mapped to distinct sites on the genome so far.
A subset of these regions highlight novel genes, said Soren Impey, assistant professor of neurology at the Oregon Health & Science University School of Medicine and the study's lead author.
The research is described in the Dec. 29 edition of the journal Cell.
Source: United Press International
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